BIO 5326 - Molecular Medicine

Handouts

	Date	Topic	Lecturer
1	Jan 13	Ligand binding and linkage	Di Cera
2	Jan 15	Enzyme kinetics	Di Cera
3	Jan 20	Molecular recognition: driving forces and mechanisms	Di Cera
4	Jan 22	Molecular recognition: allostery	Di Cera
5	Jan 27	Rational drug design: COX2 and thrombin inhibitors	Di Cera
6	Jan 29	Maintaining the integrity of the vasculature: the structure of blood vessels and platelets; the organization of the blood coagulation and fibrinolytic systems. Platelet adhesion and two disorders: von Willebrand disease and thrombotic thrombocytopenic purpura	Sadler
7	Feb 03	Making, breaking, and preventing blood clots: initiation and propagation of blood coagulation; fibrin self-assembly; regulation of fibrin degradation; oral anticoagulants	Sadler
8	Feb 05	Hemophilia, biochemistry to bedside: regulation of factor X activation in time and space; medical consequences of factor VIII and factor IX mutations; treatment of hemophilia with recombinant factor VIII, factor IX, or factor VIIa	Sadler
9	Feb 10	Innate immunity: protecting self and processing altered self	Atkinson
10	Feb 12	Human disease resulting from deficient complement activation	Atkinson
11	Feb 17	Human disease resulting from deficient complement regulation	Atkinson
12	Feb 19	Diabetes: ATP-sensitive K⁺ channels. I.	Nichols
13	Feb 24	Diabetes: ATP-sensitive K⁺ channels. II.	Nichols
14	Feb 26	Diabetes: ATP-sensitive K⁺ channels. III.	Nichols
	Mar 03	Reading period - no class
	Mar 05	MIDTERM EXAM
	Mar 10	Spring Break - No class
	Mar 12	Spring Break - No class
15	Mar 17	Diabetes: fatty acids and CD36. I	Abumrad
16	Mar 19	Diabetes: fatty acids and CD36. II	Abumrad
17	Mar 24	Diabetes: fatty acids and CD36. III	Abumrad
18	Mar 27	Alzheimer's disease: overview and pathophysiology	Goate
19	Mar 31	Is Aß central to Alzheimer's disease pathogenesis?	Goate
20	Apr 02	How does APOE modify risk for Alzheimer's disease?	Fagan
21	Apr 07	What is a biomarker and why do we need them?	Fagan
22	Apr 9	Metabolism of CSF proteins, a new tool for drug testing	Bateman
23	Apr 14	The Notch receptor. I.	Kopan
24	Apr 16	The Notch receptor. II.	Kopan
25	Apr 21	Host/pathogen interactions in sepsis	Marshall
26	Apr 23	Therapeutic approaches to sepsis	Marshall
27	Apr 28	Therapeutic approaches to AIDS	Marshall
	May 05	FINAL EXAM

BIO 5326 - Molecular Medicine

Handouts

Date

Topic

Lecturer

1

Jan 13

Ligand binding and linkage

2

Jan 15

Enzyme kinetics

3

Jan 20

Molecular recognition: driving forces and mechanisms

4

Jan 22

Molecular recognition: allostery

5

Jan 27

Rational drug design: COX2 and thrombin inhibitors

6

Jan 29

Maintaining the integrity of the vasculature: the structure of blood vessels and platelets; the organization of the blood coagulation and fibrinolytic systems. Platelet adhesion and two disorders: von Willebrand disease and thrombotic thrombocytopenic purpura

7

Feb 03

Making, breaking, and preventing blood clots: initiation and propagation of blood coagulation; fibrin self-assembly; regulation of fibrin degradation; oral anticoagulants

8

Feb 05

Hemophilia, biochemistry to bedside: regulation of factor X activation in time and space; medical consequences of factor VIII and factor IX mutations; treatment of hemophilia with recombinant factor VIII, factor IX, or factor VIIa

9

Feb 10

Innate immunity: protecting self and processing altered self

10

Feb 12

Human disease resulting from deficient complement activation

11

Feb 17

Human disease resulting from deficient complement regulation

12

Feb 19

Diabetes: ATP-sensitive K+ channels. I.

13

Feb 24

Diabetes: ATP-sensitive K+ channels. II.

14

Feb 26

Diabetes: ATP-sensitive K+ channels. III.

Nichols

Mar 03

Reading period - no class

Mar 05

MIDTERM EXAM

Mar 10

Spring Break - No class

Mar 12

Spring Break - No class

15

Mar 17

Diabetes: fatty acids and CD36. I

16

Mar 19

Diabetes: fatty acids and CD36. II

17

Mar 24

Diabetes: fatty acids and CD36. III

18

Mar 27

Alzheimer's disease: overview and pathophysiology

19

Mar 31

Is Aß central to Alzheimer's disease pathogenesis?

20

Apr 02

How does APOE modify risk for Alzheimer's disease?

Fagan

21

Apr 07

What is a biomarker and why do we need them?

Fagan

22

Diabetes: ATP-sensitive K⁺ channels. I.

Diabetes: ATP-sensitive K⁺ channels. II.

Diabetes: ATP-sensitive K⁺ channels. III.