September 18, 2007
"Translation" movie from 1971.
Sign up sheet will be present.
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September 25, 2007
Peter Burgers
"Yeast DNA Polymerase {epsilon} Participates in Leading-Strand DNA Replication "
Reference: Pursell, Z.F., Isoz, I., Lundström, E-B., Johansson, E., and Kunkel, T.A..
Science 317:127-130 (2007). |
October 2, 2007
Edwin Antony
"The Chromatin-remodeling Enzyme ACF is an
ATP-dependent DNA Length Sensor that Regulates
Nucleosome Spacing"
Reference: Yang, J.G., Madrid, T.S., Sevastopoulos, E. & Narlikar, G.J.
Nature Structural & Molecular Biology 13:1078-1083 (2006) |
October 9, 2007
Colin Wu
"Single-Molecule Studies Reveal Dynamics of DNA Unwinding by the Ring-Shaped T7 Helicase"
Reference: Johnson, D.S., Bai, L., Smith, B.Y., Patel, S.S. and Wang, M.D.
Cell 129:1249-50 (2007). |
October 16, 2007
Tim Lohman
"NS3 Helicase Actively Separates RNA Strands
and Senses Sequence Barriers Ahead of the
Opening Fork"
Reference: Cheng, W., Dumont, S., Tinoco, Jr., I. and Bustamante, C.
PNAS 104:13954-13959 (2007). |
October 23, 2007
Cindy Montana
"A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors "
Reference: Maerkl, S.J. and Quake, S.R.
Science 315:233-237 (2007) |
October 30, 2007
Geoffrey Ravilious
"A Hand-Off Mechanism for Primosome Assembly in Replication
Restart"
Reference: Lopper, M., Boonsombat, R., Sandler, S.J. and Keck, J.L.
Mol Cell 26:781-793 (2007)
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November 6, 2007
Kathleen Hall
"Crystal Structure of Human DGCR8 Core"
Reference: Sohn, S.Y., Bae, W.J., Kim, J.J., Yeom, K-H., Kim, V.N. and Cho, Y.
Nat Struct Mol Biol 14:847-853 (2007) |
November 13, 2007
Sara Binz
"Mechanisms by Which Bloom Protein Can Disrupt Recombination Intermediates
of Okazaki Fragment Maturation"
Reference: Bartos, J.D., Wang, W., Pike, J.E. and Bambara, R.A.
J Biol Chem. 281:32227-32239 (2006) |
November 20, 2007
Haifeng Jia
"DEAD-Box Proteins Unwind Duplexes by Local Strand Separation"
Reference: Yang, Q., Del Campo, M., Lambowitz, A.M. and Jankowsky, E.
Molecular Cell 28:253-263 (2007) |
November 27, 2007
Alaji Bah
"Structural Basis for the Methylation State-Specific Recognition of Histone
H4-K20 by 53BP1 and Crb2 in DNA Repair"
Reference: Botuyan, M.V., Lee, J., Ward, I.M., Kim, J-E., Thompson, J.R., Chen, J. and Mer, G.
Cell 127:1361-1373 (2006) |
December 4, 2007
Eric Tomko
"Dynamic Basis for One-Dimensional DNA Scanning by the Mismatch Repair Complex
Msh2-Msh6"
Reference: Gorman, J., Chowdhury, A., Surtees, J.A., Shimada, J., Reichman, D.R., Alani, E. and Greene, E.C.
Molecular Cell 28:359-370 (2007) |
December 11, 2007
John Majors
"Induction of Pluripotent
Stem Cells from Adult Human Fibroblasts by Defined Factors"
Reference: Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M. Ichisaka, T., Timoda, K. and Yamanaka, S.
Cell 131:861-872 (2007)
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December 18, 2007
Jason Maynes
"Hole-ly Cow: Structural Studies on Immune Complement Pore
Formation"
References:
Hadders, M.A., Beringer, D.X. and Gros, P.
Structure of C8alpha-MACPF reveals mechanism of membrane attack in
complement immune defense.
Science 317:1552-1554 (2007).
Rosado, C.J., Buckle, A.M., Law, R.H., Butcher, R.E., Kan, W.T., Bird, C.H., Ung, K., Browne,
K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike,
R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J.,
Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., and Whisstock,
J.C.
A common fold mediates vertebrate defense and bacterial attack.
Science 317:1548-1551 (2007). |