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F. Scott Mathews
Professor
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research Interests
X-ray structure and analysis of macromolecules
Selected Publications
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Kommoju, P.R., Bruckner, R.C., Ferreira, P., Carrell, C.J., Mathews, F.S., and Jorns, M.S. Factors that affect oxygen activation and coupling of the two redox cycles in the aromatization reaction catalyzed by NikD, an unusual amino acid oxidase. Biochemistry (E-pub ahead of print.) (2009).
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Sukumar, N., Dewanti, A., Merli, A., Rossi, G.L., Mitra, B. and Mathews, F.S. Structures of the G81A mutant form of the active chimera of (S)-mandelate dehydrogenase and its complex with two of its substrates. Acta Crystallogr D Biol Crystallogr 65:543-552 (2009).
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Hassan-Abadallah, A., Zhao, G., Chen, Z., Mathews, F.S. and Schuman Jorns, M. Arginine 49 is a bifunctional residue important in catalysis and biosynthesis of monomeric sarcosine oxidase: A context-sensitive model for the electrostatic impact of arginine to lysine mutations. Biochemistry 47:2913-2922 (2008).
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Gandhi, P.S., Chen, Z., Mathews, F.S. and Di Cera, E. Structural identification of the pathway of long-range communication in an
allosteric enzyme. Proc Natl Acad Sci U S A. 105:1832-1837 (2008).
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Ma, J.K., Wang, Y., Carrell, C.J., Mathews, F.S. and Davidson, V.L. A single methionine residue dictates the kinetic mechanism of interprotein electron transfer from methylamine dehydrogenase to amicyanin(,).
Biochemistry 46:11137-11146 (2007).
