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Tom Ellenberger
Wittcoff Professor and Head
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research
Research in the Ellenberger laboratory focuses on the molecular structures and cellular functions of proteins that replicate DNA, repair chemical damage, and regulate chromatin structure. These enzymes and regulatory proteins ensure the faithful transmission of our genetic blueprint to future generations.
Selected Publications
- Antony, E., Tomko, E.J., Xiao, Q., Krejci, L, Lohman, T.M. and Ellenberger, T. Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA. Molecular Cell 35:105-115 (2009).
- Etzion, Y., Hackett, A., Proctor, B.M., Ren, J., Nolan, B., Ellenberger, T. and Muslin, A.J. An unbiased chemical biology screen identifies agents that modulate uptake of oxidized LDL by macrophages. Circ Res 105:148-157 (2009).
- Song, W., Pascal, J.M. and Ellenberger, T. and Tomkinson, A.E. The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps. DNA Repair 8:912-919 (2009).
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Raschle, M., Knipsheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J.D., Ellenberger, T.E., Scharer, O.D. and Walter, J.C. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134:969-980. (2008).
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Zhong, S., Chen, X., Zhu, X., Dziegielewska, B., Bachman, K.E., Ellenberger, T., Ballin, J.D., Wilson, G.M., Tomkinson, A.E. and MacKerell, Jr., A.D. Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem 51:4553-4562 (2008).
