Tom Ellenberger

Post-doctoral positions are available to study the molecular structures and cellular functions of proteins involved in DNA metabolism (replication, repair, recombination and chromatin modifying proteins). Applicants should possess a strong background in biochemistry, with experience in protein purification and functional characterization. Experience in x-ray crystallography and/or cell culture is preferred but not required. Interested candidates must be self-motivated with strong communication skills. Please see my lab webpage for more information.

Interested candidates should send their c.v. and three letters of reference to:

Dr. Tom Ellenberger
Wittcoff Professor and Head
Dept. of Biochemistry and Molecular Biophysics
Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8231
St. Louis, MO 63110
Tel: 314-362-0287
Fax: 314-362-4432

Or send e-mail to tome@biochem.wustl.edu.

Elliot Elson

Gregory Goldberg and Elliot Elson have a postdoctoral position to investigate mechanistic and functional properties of matrix metalloproteinases. In particular we are interested in the dynamic interactions of these enzymes with substrate fibrils in relation to their ability to degrade extracellular matrix molecules and to contribute to cell locomotion and matrix remodeling. Applicants should possess a strong background in cell biology and/or molecular biophysics. Please see the following papers for background of these studies.

• Collier, I. E., S. Saffarian, B. L. Marmer, E. L. Elson and G. Goldberg (2001). "Substrate recognition by gelatinase a: the c-terminal domain facilitates surface diffusion." Biophys J 81(4): 2370-7.
• Saffarian, S., I. E. Collier, B. L. Marmer, E. L. Elson and G. Goldberg (2004). "Interstitial collagenase is a Brownian ratchet driven by proteolysis of collagen." Science 306(5693): 108-11.
• Strongin, A. Y., I. Collier, G. Bannikov, B. L. Marmer, G. A. Grant and G. I. Goldberg (1995). "Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease." J Biol Chem 270(10): 5331-8.

Interested candidates should send their c.v. and three letters of reference to:

Dr. Ellliot Elson
225 McDonnell Science Building
Washington University School of Medicine
Dept. of Biochemistry & Molecular Biophysics
660 S. Euclid Avenue
Campus Box 8231
St. Louis, MO 63110
Tel: 314-362-3346
Fax: 314-362-7183


Or send e-mail to: elson@wustl.edu and/or Goldberg@beckermail.wustl.edu

Roberto Galletto

One Postdoctoral position is available to study telomere dynamics and role of motor proteins with an integrated approach of ensemble and single-molecule techniques. Expertise in protein purification and characterization, enzymatic activity, equilibrium and kinetic analysis of protein-DNA interactions is preferred.

Interested candidates should send their c.v. and three letters of reference to:

Dr. Roberto Galletto
Assistant Professor
252 McDonnell Science Building
Washington University School of Medicine
Dept. of Biochemistry & Molecular Biophysics
660 S. Euclid Avenue
Campus Box 8231
St. Louis, MO 63110
Tel: 314-362-4368
Fax: 314-362-7183


Or send e-mail to: Dr. Roberto Galletto

Timothy M. Lohman

Postdoctoral positions are available for studies of DNA motor proteins (helicases) involved in DNA repair and SSB protein-DNA interactions using biochemical, biophysical and mutational approaches. Particular emphasis is on mechanistic studies using transient kinetic methods (fluorescence, stopped-flow, quenched-flow) as well as thermodynamic (equilibrium binding and isothermal titration calorimetry, analytical ultracentrifugation) and structural (x-ray crystallography) approaches. Please see my home page.

Interested candidates should send their c.v. and three letters of reference to:

Dr. Timothy M. Lohman
Washington University School of Medicine
Dept. of Biochemistry & Molecular Biophysics
660 S. Euclid Avenue
Campus Box 8231
St. Louis, MO 63110

Or send e-mail to: Dr. Timothy M. Lohman